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Taking Accutane for Acne

By Nicole Galan, RN, About.com

Updated November 04, 2008

About.com Health's Disease and Condition content is reviewed by the Medical Review Board

What is Accutane?:
Accutane is an acne treatment, usually reserved for when traditional acne medications do not work. A form of vitamin A, it works by reducing the amount of oil that the sebaceous glands produce.
Accutane and Pregnancy:
Due to the link to severe birth defects even after a single dose, it is extremely important to not get pregnant while taking this drug. Available through iPledge, there are certain rules that must be followed to ensure safety.
What are the iPledge Requirements?:
You must have a negative pregnancy test drawn at an iPledge-approved lab before each prescription is filled. You must agree to use two forms of birth control the entire time you take this drug. You must fill the prescription within seven days of it being written, and you can only obtain 30 days worth of medication at a time. Finally, you must log on to the iPledge computer system and answer a series of questions before filling each prescription. While it may seem like a bit of a pain, these precautions are necessary in order to protect the health of an unborn children.
How Do I Take Accutane?:

Make sure to take your medication exactly as your physician prescribed it for you, usually once or twice a day. You will take Accutane for 16 to 20 weeks, followed by a brief rest. Occasionally, a patient may need to take a second round of Accutane if a relapse occurs. Take this medication with food to prevent esophageal and stomach irritation.

Accutane can affect your liver and cholesterol, so some blood testing may be required. It is important to comply with your doctor’s orders to prevent any long-term complications.

Side Effects:
  • Depression or suicidal thoughts
  • dryness of the skin
  • sensitivity to light or the sun (use sunscreen!)
  • fatigue
  • nausea and vomiting
  • diarrhea or rectal bleeding
  • bone pain or weakness
Make sure to promptly notify your physician of any side effects that you may experience while taking Accutane.
Drug Interactions:
Certain antibiotics, dilantin and steroids may interact with Accutane. Let your physician know of any medications you are taking.
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