HCG in Fertility TreatmentsBecause hCG is similar in structure to LH, an injection of hCG when there is a mature egg follicle in the ovary can cause the egg to mature and be released. The medication can be used alone, in an ovulation induction cycle as with intrauterine insemination or during in vitro fertilization. hCG will cause ovulation approximately 36 hours after you take it, allowing your doctor to better time intrauterine insemination or the egg retrieval.
Preparing/Mixing hCGOne form of hCG, Ovidrel, comes in a 250mcg prefilled syringe. Once you open the box, the medicine is already prepared and loaded in the syringe with the needle attached. Simply open the packaging, remove the air bubble by holding the syringe with the needle facing up and slightly depress the plunger until all the air is removed, and inject the medication subcutaneously.
hCG (Human Chorionic Gonadotropin, Pregnyl or Novarel) also comes in a box with a 10,000 unit vial of powder and a vial of diluent (liqiuid) which is used to mix the powder. Your doctor will tell you how many units of the medicine to take and how they prefer you to mix it. For example, if you are taking 10,000 units, you will remove 2mLs of diluent and inject it into the powder. Allow the powder to dissolve and then pull the entire 2mLs back into the syringe. Inject the medication intramuscularly or subcutaneously, according to your doctor’s instructions.
When Do I Take HCG During my Cycle?
This medication is taken once there is a mature egg follicle in the ovary. Your doctor will most likely give you a specific time or time frame to take the medication. It is important to tell your doctor if you do not take the medication on time in case any adjustments need to be made. If you will be having intercourse or intrauterine insemination, ovulation will occur approximately 36 hours later, so the day of the injection and two days following it are your critical days. If you will be having egg retrieval as in an IVF cycle, it will occur close to that 36-hour mark so as to optimize the maturation but avoid ovulation.